Glgc gwas
WebFeb 9, 2024 · To mimic the GLGC test set which consisted of European cohorts, we randomly sampled 19,840 individuals from 276,791 unrelated individuals of white British ancestry in the UK BioBank WebJun 30, 2024 · The replication rates are high for all four methods: among the significant genes identified in the GLGC GWAS, 161 out of 200 (81%), 79 out of 108 (73%), 93 out of 120 (77%), and 52 out of 69 (75%) were …
Glgc gwas
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WebNov 4, 2016 · For GWAS, linkage disequilibrium is a source of confounding marker dependencies. MSEA was less sensitive to LD thresholds for better powered studies such as the GLGC GWAS but smaller studies benefited from less stringent LD cutoffs, presumably due to improved statistical power (Additional file 2: Figure S1). WebVariant set derived from blood-lipid GWAS results from GLGC and HUNT consortium Integrated transcript- and variant-level functional annotations via Ensembl Variant Effect Predictor
WebApr 27, 2024 · We also evaluated the effects of lipid concentrations on AAD. Summary statistics from the Global Lipids Genetics Consortium (GLGC) GWAS, which identified more than one hundred lipid-associated loci, were applied in the present study (42, 43). The “high cholesterol” GWAS included 55,265 cases and 396,999 controls. The “Disorders of ... WebNov 26, 2013 · JOINT ANALYSIS OF METABOCHIP AND GWAS DATA LDL Cholesterol HDL Cholesterol Triglycerides Total Cholesterol ANALYSIS OF METABOCHIP DATA …
http://csg.sph.umich.edu/willer/public/lipids2013/ WebIncreased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication …
WebMar 11, 2024 · Genetic association estimates for LDL-c were obtained from a meta-analysis of genome-wide association studies (GWAS) conducted by the Global Lipids Genetics Consortium (GLGC). 19 The meta-analysis was restricted to participants of European ancestry, and most contributing cohorts measured blood lipid levels after 8 or more hours …
WebOct 30, 2024 · The in silico replication study was conducted with data from additional independent individuals of European ancestry from the Nord-Trøndelag Health Study (HUNT) 19 and GLGC GWAS 2, and Chinese ... david sholes riWebAug 8, 2024 · The only associations that did not replicate in GLGC were those that were not predicted at all due to lack of SNP overlap between the GLGC GWAS summary results and the expression prediction models. All 44 of the GLGC associations also met the more stringent threshold of P < 8.5×10 −4 , the Bonferroni adjustment for 59 tests. david s hollis pls peWeb(1) Mapping of GLGC GWAS Meta-analysis SNPs to Genes—The GLGC GWAS meta-analyses data is based on 46 lipid/lipoprotein GWAS involving over 100,000 individuals of European descent as ascertained in the United States, Europe, or Australia (16). The GLGC consortium contributed genome wide analysis data for analyses, davidshof oldenswortWebWe first performed a GWAS including a discovery phase in MVP and a replication phase in the Global Lipids Genetics Consortium (GLGC) (Fig. 1). In the discovery phase (Stage … david shoham loyola university hospitalWebUsing GWAS and comorbidity data, we present a network-based approach to predict candidate genes for lipid and lipoprotein traits. We apply a prediction pipeline incorporating interactome, co-expression, and comorbidity data to Global Lipids Genetics Consortium (GLGC) GWAS for four traits of interest, identifying phenotypically coherent modules. gaston county police reportsWebThe Global Lipids Genetics Consortium aggregated GWAS results from 1,654,960 individuals from 201 primary studies representing five genetic ancestry groups: Admixed … gaston county planning and zoningWebNov 13, 2024 · Upload and share GWAS results with my.locuszoom.org ~ October 14, 2024 We are happy to announce the newest stage in our efforts to support interactive, exploratory GWAS plots: the new my.locuszoom.org upload-to-plot service. This new service generates fully interactive plots, with no limits on the number of loci you can explore. gaston county police frequencies