Neotanshinlactone
WebIn our previous study, neo-tanshinlactone (1) showed potent and selective anti-breast cancer activity. To explore the SAR of 1, nine analogues (15−18, 24−28) were designed and … Webneotanshinlactone Medicine & Life Sciences 100%. Structure-Activity Relationship Medicine & Life Sciences 49%. Antineoplastic Agents Medicine & Life Sciences 40%. Antineoplastic Agent Chemical Compounds 37%. Breast Neoplasms Medicine & Life Sciences 26%. Heterografts Medicine & Life Sciences 25%.
Neotanshinlactone
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WebDec 1, 2010 · Natural and synthetic coumarins have been found to exhibit a variety of pharmacological activities like anti-HIV, 9 anticoagulant, 10 antibacterial, 11 antioxidant, 12 and anti-inflammatory. 13 Among the diverse biological activities of coumarin the most intriguing bioactivity is the effect against breast cancer.14, 15, 16 Figure 1 shows the … WebBreast cancer, the most frequent cancer in women, is the second leading cause of cancer-related death. Estrogens and estrogen receptors are well recognized to play predominant …
WebMar 14, 2024 · Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents WebOct 1, 2016 · Request PDF Neo-tanshinlactone D-Ring Modified Novel analogues Induce Apoptosis in Human Breast Cancer Cell via DNA Damage Neo-tanshinlactone (NTL) a …
WebDec 1, 2010 · A small library of novel benzocoumarin derivatives based on naturally occurring neo-tanshinlactone scaffold was constructed and their antiproliferative activities … WebMar 11, 2010 · Neo-tanshinlactone (1) and its previously reported analogues, such as 2, are potent and selective in vitro antibreast cancer agents. The synthetic pathway to 2 was optimized from seven to five steps, with a better overall yield. Structure-activity relationships studies on these compounds revealed so …
WebSep 1, 2016 · To test in vitro anti-proliferative activity of neo-tanshinlactone, two ER+ breast cancer cell lines (MCF7 and ZR-75-1), three ER- breast cancer cell lines (MDA-MB-231, BT-549 and HCC1937) and one prostate cancer cell line LNCaP were treated with a serial of neo-tanshinlactone concentrations ranging from 0.2 μM to 20 μM for 72 h.As …
gb 17914WebNov 15, 2009 · Tetrahydroneotanshinlactone (TNT) and tetrahydronaphthalene-1-ol (TNO) derivatives were designed, synthesized, and evaluated for cytotoxic activity. The TNO … gb 17945—2018WebJan 1, 2024 · Neo-tanshinlactone (NTL) a natural product is known for its specificity and selectivity towards the breast cancer cells. By NTL D-ring modification approach, 13 new … gb 17945下载WebSep 1, 2016 · To test in vitro anti-proliferative activity of neo-tanshinlactone, two ER+ breast cancer cell lines (MCF7 and ZR-75-1), three ER- breast cancer cell lines (MDA-MB-231, … gb 17945 2010WebMar 23, 2010 · ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. gb 17945锛 010WebJun 20, 2024 · Several neo-tanshinlactone derivatives with fluorine or the trifluoromethyl group were synthesized and their antiproliferative activities were evaluated. Compared … autohotkey keys listWebJan 1, 2024 · Worldwide 1.2 million breast cancer (BC) cases were estimated per year and that remains a common cause of mortality and morbidity in woman, despite advancement in therapy and early diagnosis. 1 Various natural products are known to kill the cancer cells in vitro as well as in vivo studies. Drug discovery in the treatment of cancer was … autohotkey keyboard mapping